Feb 17, 2020
It is a challenge in our modern
society to be a truly original thinker, to stand by your beliefs in
the face of criticism until you end up proving everybody wrong.
This is especially true in hotly debated topics such as health and
diet, and their connection to longevity. Today’s guest, Dr. David
Sinclair, is one such thought leader in this very subject, and he
joins us on the show to speak about his groundbreaking ideas on
epigenetics and longevity that can be found in his new
book Lifespan. Dr. Sinclair is responsible for
NAD, one of the best longevity supplements that exist. He also
pioneered the resveratrol research which had a highly controversial
reception at first but which is now largely accepted in the
scientific community. In this episode, Dr. Sinclair sits down to
discuss a whole plethora of incredibly fascinating biological
processes that play a role in aging.
He gets into how habits of diet,
exercise, contact with chemicals and vibrations, and the intake of
a range of different drugs and molecules can intervene in these
processes either negatively, or with almost fantastical levels of
effectiveness. He gives us all the information we need to know
about resveratrol, metformin, protein, mTOR, rapamycin, sirtuins,
NAD, and AMPAkines, talking about their functions in monitoring and
optimizing the body at the epigenetic level. Dr. Sinclair’s
commitment to demystifying this vast space is commendable, so this
is definitely an episode you should check out, and bring a pen and
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- Introducing Dr. Sinclair and
Lifespan which dissects why we age. [1:08]
- How societally orchestrated fear
encourages consumerism, reducing longevity. [5:52]
- The evolutionary rationale behind
rewarding the brain for exercise. [9:00]
- Why it is valuable to create stern
rules around junk food: willpower no longer factors in.
- Longevity pathways in relation to
resveratrol, metformin, protein, and exercise. [13:15]
- Using workouts to gain muscle
while fasting and taking resveratrol and metformin.
- Questions of whether protein,
mTOR, rapamycin, or meat-eating increases longevity.
- Definitions of AMPAkines, mTOR,
sirtuins, and NAD, and their role in energy levels.
- How sirtuins help the body live in
many ways but are dependent on NAD levels. [27:33]
- Ways to encourage sirtuin amounts:
fasting, exercise, cold and heat exposure. [29:49]
- Dr. Sinclair’s previously
controversial research which proved resveratrol increased
- More on the controversy on
resveratrol’s effects relating to specific enzymes it seeks.
- Recommended resveratrol daily
dosage and overdose quantities. [40:51]
- Benefits of metformin for diabetes
2, heart disease, frailty, and Alzheimer’s. [42:40]
- Downsides of metformin related to
timing and reduction in energy/muscle building. [45:13]
- Effects of rapamycin which seem to
reduce or increase longevity depending on dose. [47:44]
- Impacts inflammation and being
overweight have on immune activity and longevity.
- How CD38 blocks NAD and telomeres
are one of the causes of aging. [52:45]
- A major cause of aging: epigenetic
changes over time. [54:49]
- Ways to regulate epigenetic
changes: sirtuin proliferation. [57:25]
- New research of Dr. Sinclair’s
which ‘reboots’ cells, reversing mouse blindness.
- Structured water, protein
misfolding, and their role in aging. [1:04:51]
- DNA breaks which occur in our
bodies and how to minimize them: raising NAD, etc.
- Things that encourage DNA
breaking: x-rays, CT scans, microwaved plastics, inks.
- Ways Dr. Sinclair mitigates free
radical exposures: fasting, and taking NAD. [1:13:36]
- Whether NAD is right for younger
people: read page 303 of Lifespan. [1:13:36]
- Womb activity and constant feeding
which sets kids up for bad health. [1:19:28]